2026 outlook

Global M&A trends in health industries

Global M&A trends in health industries hero image
  • Insight
  • 8 minute read
  • January 27, 2026

Health industries dealmakers are seeking to build resilience, secure capabilities, and reposition for growth. In 2026, M&A will be driven by derisked innovation, technology, shifting funding models, and the consumerisation of care.

by Jaymal Patel

Accelerating reinvention across care, science, and data

Health industries dealmakers are starting 2026 with renewed confidence and strategic urgency. After two years of navigating macroeconomic volatility and regulatory uncertainty, we see acceleration, rather than stabilisation, defining the M&A environment.

Four forces will shape the deal landscape in 2026:

  • Pursuit of resilience, with buyers prioritising assets that feature high-quality innovation, robust data, recurring cash flows, and steady margins
  • Value creation and exit readiness, as both corporates and financial investors prepare for exit windows that may reopen quickly
  • Consumer-centric, tech-enabled care, in which data, automation, and AI shape how, where and by whom healthcare is delivered
  • Global rebalancing of innovation, with China and other emerging research hubs scaling discovery capabilities and challenging long-standing US and European dominance

Investors are entering 2026 with a renewed appetite for deals. Last year’s activity was shaped by the M&A “triple threat” of tariffs, drug pricing pressures, and regulatory shifts—conditions that steered buyers towards targeted transactions, such as those that filled critical pipeline gaps. As 2026 unfolds, leading health industries players are making bolder moves that reposition portfolios for a future in which every part of the healthcare value chain, from drug discovery to care delivery, is being redefined.

$1tn

By 2035, more than $1tn in global healthcare spending is projected to shift towards prevention, personalised care, home-based services and digital ecosystems, reshaping value pools across every sector.

Source: PwC’s From breaking point to breakthrough: the $1 trillion opportunity to reinvent healthcare report, 2025

M&A remains the fastest and most effective way to modernise operations, accelerate scientific and digital innovation, and build the capabilities required for prevention-led, personalised, and care-anywhere models. The deals that stand out will be those backed by differentiated data and evidence-backed innovation, AI-enhanced productivity, and clear pathways to long-term value creation. In a more competitive and globalised innovation environment, the companies that act early and with conviction will be best positioned to shape the next era of healthcare.

The winners will be those that transact early, reshape their portfolios with strategic focus, and embed AI-driven efficiencies across R&D, clinical development and operations. 

‘In 2026, the most successful deals will be the ones that seek to shape the future of healthcare, creating a more resilient, tech-enabled, affordable and patient-centred health system.’

Jaymal Patel,Global Health Industries Deals Leader, PwC UK

Spotlight on China Life sciences dealmaking looks east

China is reshaping the global innovation map for the pharmaceutical industry. The country now accounts for roughly one-third of global clinical trials, surpassing Europe in several therapeutic areas, and it has become the world’s second-largest developer of new medicines after the US.

Regulatory change is reshaping the innovation playing field

Regulatory reforms have accelerated approval timelines and reduced R&D costs, enabling Chinese biotechs to move from drug discovery to human trials at a pace unmatched in many mature markets. A vast patient population further supports faster recruitment and data collection. At the same time, regulatory uncertainty in the US has added friction to traditional drug development pathways, prompting multinational companies to look to China for partnerships, licensing deals, and co-development opportunities that can help fill critical pipeline gaps and deliver cost-efficient, timely clinical development.

Cross-border deal models are unlocking access to Chinese innovation

These dynamics are leading Western pharmaceutical companies to seek access to innovation originating in China, in turn fueling a surge in deal activity structured around two complementary models: traditional license-out agreements and NewCo formations.

In the license-out model, Chinese biotechs grant rights to co-develop or commercialise drugs in other markets, allowing global partners to advance late-stage development while the originating company retains upstream value. Pfizer’s licensing agreement with 3SBio, which included $1.25bn upfront and up to $4.8bn in milestones for a PD-1/VEGF bispecific, illustrates the scale and maturity of assets now attracting global demand.

In parallel, the NewCo structure is also gaining traction as an alternative pathway for global development. Under this model, Chinese biotechs transfer assets into a newly capitalised entity alongside overseas investors, enabling global development while preserving domestic equity upside. Hengrui Pharma’s licensing of its Phase 3 cardiac myosin inhibitor HRS-1893 to US biotech Braveheart Bio illustrates the NewCo model in action, with Hengrui retaining greater China rights while securing upfront capital, milestones and royalties, and Braveheart gaining exclusive global development and commercialisation rights outside China to build a focused cardiovascular franchise.

The chart below illustrates recent trends in China’s outbound drug licensing, highlighting both deal counts and upfront payments.

In 2025, China’s innovative drug outbound licensing activity reached record highs: $135.6bn in total deal value, $7.0bn in upfront payments, and 157 transactions. The use of NewCo models increased from six deals in 2024 to nine in 2025.

Turning China’s innovation advantage into deal success

As innovation continues to globalise, China is emerging as a central hub for life sciences dealmaking, combining speed, scale, and scientific capability that are increasingly difficult to replicate elsewhere. For dealmakers, partnering successfully with Chinese biotechs will require a deliberate approach that navigates cross-border regulatory complexity, reinforces data and intellectual property protections, and uses innovative structures to balance risk while preserving strategic flexibility.

Key M&A themes for health industries in 2026

Investors are rotating towards assets with resilient, recurring cash flows as a hedge against reimbursement uncertainty, geopolitical risk, and fluctuating interest rates. Health industries continue to navigate shifting payment and reimbursement rules, variable funding commitments, and evolving regulatory environments. With these dynamics, low-volatility platforms such as established generics, select hospital clusters, post-acute care platforms, and outpatient service networks, are attracting heightened attention from investors for their stability and predictable utilisation patterns. The occupational health and corporate well-being market provides an example of strong investor interest as healthcare funding shifts from the state to corporates, driven by rising consumer demand alongside tightening public budgets. Consolidation in this sector is under way across developed markets.

CapVest’s proposed acquisition of STADA, a German consumer healthcare, generics and specialty pharmaceuticals company, illustrates the sustained investor appetite for defensible assets with stable demand profiles, supported by essential medicines and consumer healthcare products that are less exposed to shifts in public reimbursement. Similar dynamics are playing out across healthcare services, where elderly care models and a recurring revenue outpatient network continue to draw interest from both strategic buyers and financial investors. 

Exit windows will remain narrow in 2026, constrained by volatile public market valuations, selective buyer appetite, and lingering uncertainty around regulatory, pricing and macroeconomic conditions. As issuers and investors grow more confident, we expect IPO markets to begin offering more viable exit opportunities for health industries companies, particularly those in categories such as AI-enabled care, digital platforms, and medtech, where sponsor and crossover investor interest has strengthened. Medline’s debut on the Nasdaq in mid-December 2025, which raised $7.26bn in the largest IPO in nearly five years, exemplifies this strengthening confidence. Biotech, however, remains uneven, and while public markets are opening for late-stage, data-rich, and derisked assets, much of the earlier-stage cohort remains constrained.

Given these dynamics, many sellers may pursue dual-track processes, exploring an IPO alongside a potential sale to a corporate or financial investor to preserve optionality and maximise their chances of success. This will increase pressure on companies to be well prepared ahead of process launch, with particular emphasis on articulating a clear, evidence-backed growth, and value creation story.

As more financial investors approach the end of holding periods, we expect a steady pipeline of divestitures and secondary transactions. Early examples of this trend include Thermo Fisher’s $8.9bn proposed acquisition of private-equity-backed clinical trial data analytics provider Clario and Abbott’s $21bn proposed purchase of cancer screening and diagnostic testing company Exact Sciences.

Looking ahead to 2026 and beyond, many assets are likely to come to market with strengthened operational narratives, cleaner data, and more explicit technology roadmaps, giving buyers greater confidence whether evaluating potential IPO prospects, strategic exits, or financial investor-led transactions.

Consumer expectations are reshaping health industries as patients demand more convenient, prevention-oriented, and tech-enabled care. Platforms that can deliver experiences such as virtual-first primary care, home diagnostics, remote patient monitoring, and wellness ecosystems are expected to command premium valuations. Recent deals such as Resmed’s acquisition of virtual diagnostics company VirtuOx and Samsung’s acquisition of digital health company Xealth illustrate how buyers are accelerating their shift towards virtual and care-anywhere platforms.

At the same time, GLP-1 therapies continue to influence demand patterns across biopharma, nutrition, retail, and chronic care. The intense competition for Metsera, which Pfizer ultimately acquired in November 2025, underscores the urgency with which buyers are looking to secure next-generation obesity and metabolic treatments. Ripple effects are expanding beyond obesity into cardiometabolic disease, nonalcoholic steatohepatitis, and adjunctive behavioural health support. This in turn is attracting interest from across the medtech, digital health, and retail ecosystem. Strategic buyers are also pursuing assets across the GLP-1 supply chain, including manufacturing capacity, formulation technologies, and delivery mechanism, as demand continues to outpace supply.

As consumer behaviour shifts and therapeutic markets evolve, investors are prioritising platforms that combine strong engagement, data-driven personalisation, and clear pathways to value-based growth. These factors will remain central to valuation and deal momentum in 2026.

Large pharmaceutical companies continue to face significant loss-of-exclusivity cliffs, increasing the pressure to replenish late-stage pipelines with assets that offer differentiated data, clear regulatory pathways, and commercial readiness. As a result, buyers are concentrating on derisked innovation such as programmes with proven biology, robust trial results, and well-defined routes to approval. Radiopharmaceuticals, RNA therapies, cardiometabolic drugs, immunology, vaccines, and antibody-drug conjugates are among the most active dealmaking hotspots. In addition, buyers are increasingly attracted to companies as potential M&A targets that are differentiated by emerging platform capabilities such as AI-enabled trial design, modern imaging modalities, real-world-evidence integration, and autonomous safety workflows.

Recent deals such as Novartis’s $12bn acquisition of Avidity Biosciences, Merck’s $10bn acquisition of Verona Pharma, Roche’s $3.5bn acquisition of 89bio, and Sanofi’s $2.2bn acquisition of Dynavax illustrate the size and scale of deals we expect to see in 2026. Activity is expected to remain focused on acquisitions that strengthen and complement treatment portfolios while accelerating innovation. 

Cross-border dealmaking is accelerating as innovation, talent, and capital flows become more globally distributed—driven in part by the growing healthcare needs of large, highly populated countries seeking higher-quality care at more affordable price points, as well as the ability to supply established markets more efficiently. As highlighted earlier, China’s rapidly advancing biopharma ecosystem continues to reshape global pipelines. India is also emerging as a strategic priority for both corporates and private equity.

In India, investor interest is increasingly focused on hospital platforms, such as KKR’s acquisition of oncology hospital chain Healthcare Global Enterprises, as well as scalable single-specialty networks, and complex contract development and manufacturing organisations that support global supply-chain diversification under “China+1” strategies. India’s national digital health infrastructure is enabling data-rich, AI-supported clinical workflows at scale, which is an important differentiator for cross-border partners seeking operational efficiency, cost-effective supply chains, and access to large patient populations.

As innovation globalises, new partnership structures including licensing, co-development, and NewCo models are creating fresh new pathways for global collaboration. These dynamics are expanding the opportunity set for investors while reinforcing Asia’s growing role as a driver of global biopharma and healthcare services M&A.

Medtech companies remain focused on sharpening their portfolios through divesting lower-growth or non-core assets and reinvesting in faster-growing categories. In 2025, BD’s announced sale of its advanced bioprocessing business and certain diagnostics assets to Waters Corporation for approximately $17.5bn exemplified this trend. Similar moves are underway across the sector, including carveouts in diabetes, surgical, and patient monitoring businesses, as companies concentrate on core platforms.

Financial investors are highly active, particularly in corporate carveouts, where operational efficiencies and technology enablement can unlock additional value. Many of these assets offer strong fundamentals, but greater autonomy enables clearer strategy and more targeted investment, allowing them to reach their full potential.

Across categories, next-generation technologies, such as robotics, AI-supported imaging, sensors, and home-based devices, are central to long-term strategies aligned to prevention and care-anywhere models. Medtech acquirers are prioritising targets that bring not only differentiated technology but also the data, software and service layers that support recurring revenue and stronger customer retention.

As portfolio optimisation continues and next-generation technologies scale, we expect medtech deal activity in 2026 to remain robust.

M&A outlook for health industries in 2026

In 2026, M&A will be the catalyst for business model reinvention, helping leaders unlock digital capabilities, accelerate innovation, and reposition for consumer-centred care. Deals will drive business model reinvention across all sectors, from biopharma and medtech to health services and digital health.

Cross-border partnerships will become more important. As business models evolve, divestitures will sit alongside acquisitions. And as AI matures, data-driven diligence, integration, and value creation will increasingly separate leaders from laggards.

The imperative is clear: act early, transact with purpose, and build momentum towards an AI-enabled prevention-led health system. 

Our commentary on M&A trends is based on data from industry-recognised sources and PwC’s independent research and analysis. Certain adjustments may have been made to source information to align with PwC’s industry classifications. All dollar amounts are in US dollars. Megadeals are defined as transactions valued greater than $5bn.

Global health industries deal value and volume data referenced in this publication are based on officially announced transactions, excluding rumoured and withdrawn transactions, as provided by the London Stock Exchange Group (LSEG). Data is as of 31 December 2025 and was accessed between 1 and 8 January 2026. 2025e is a PwC estimate to improve year-on-year comparability, adjusting December 2025 for a reporting lag. 2025e does not represent a PwC forecast. Figures may not sum precisely due to rounding.

Data on China’s innovative drug outbound transaction volume and value is sourced from Pharmcube (医药魔方) NextPharma® Global Innovative Drug Database. Data is as of 31 December 2025 and was accessed on 6 January 2026.

Jaymal Patel is PwC’s global health industries deals leader and a partner with PwC UK.

The author would like to thank the following colleagues from across PwC and Strategy&’s global network for their insights that informed this perspective: Stephen Aherne, Issy Corbett, Philip Dykstra, Suzanne Ellis, Roel van den Akker, Jonathan Williams, and Jia Xu. Special thanks also to Mike Proppe and Nina Bühler from PwC’s health industries deals team for their contributions. 

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