Accelerating reinvention across care, science, and data
Health industries dealmakers are starting 2026 with renewed confidence and strategic urgency. After two years of navigating macroeconomic volatility and regulatory uncertainty, we see acceleration, rather than stabilisation, defining the M&A environment.
Four forces will shape the deal landscape in 2026:
Investors are entering 2026 with a renewed appetite for deals. Last year’s activity was shaped by the M&A “triple threat” of tariffs, drug pricing pressures, and regulatory shifts—conditions that steered buyers towards targeted transactions, such as those that filled critical pipeline gaps. As 2026 unfolds, leading health industries players are making bolder moves that reposition portfolios for a future in which every part of the healthcare value chain, from drug discovery to care delivery, is being redefined.
M&A remains the fastest and most effective way to modernise operations, accelerate scientific and digital innovation, and build the capabilities required for prevention-led, personalised, and care-anywhere models. The deals that stand out will be those backed by differentiated data and evidence-backed innovation, AI-enhanced productivity, and clear pathways to long-term value creation. In a more competitive and globalised innovation environment, the companies that act early and with conviction will be best positioned to shape the next era of healthcare.
The winners will be those that transact early, reshape their portfolios with strategic focus, and embed AI-driven efficiencies across R&D, clinical development and operations.
‘In 2026, the most successful deals will be the ones that seek to shape the future of healthcare, creating a more resilient, tech-enabled, affordable and patient-centred health system.’
Jaymal Patel,Global Health Industries Deals Leader, PwC UKChina is reshaping the global innovation map for the pharmaceutical industry. The country now accounts for roughly one-third of global clinical trials, surpassing Europe in several therapeutic areas, and it has become the world’s second-largest developer of new medicines after the US.
Regulatory change is reshaping the innovation playing field
Regulatory reforms have accelerated approval timelines and reduced R&D costs, enabling Chinese biotechs to move from drug discovery to human trials at a pace unmatched in many mature markets. A vast patient population further supports faster recruitment and data collection. At the same time, regulatory uncertainty in the US has added friction to traditional drug development pathways, prompting multinational companies to look to China for partnerships, licensing deals, and co-development opportunities that can help fill critical pipeline gaps and deliver cost-efficient, timely clinical development.
Cross-border deal models are unlocking access to Chinese innovation
These dynamics are leading Western pharmaceutical companies to seek access to innovation originating in China, in turn fueling a surge in deal activity structured around two complementary models: traditional license-out agreements and NewCo formations.
In the license-out model, Chinese biotechs grant rights to co-develop or commercialise drugs in other markets, allowing global partners to advance late-stage development while the originating company retains upstream value. Pfizer’s licensing agreement with 3SBio, which included $1.25bn upfront and up to $4.8bn in milestones for a PD-1/VEGF bispecific, illustrates the scale and maturity of assets now attracting global demand.
In parallel, the NewCo structure is also gaining traction as an alternative pathway for global development. Under this model, Chinese biotechs transfer assets into a newly capitalised entity alongside overseas investors, enabling global development while preserving domestic equity upside. Hengrui Pharma’s licensing of its Phase 3 cardiac myosin inhibitor HRS-1893 to US biotech Braveheart Bio illustrates the NewCo model in action, with Hengrui retaining greater China rights while securing upfront capital, milestones and royalties, and Braveheart gaining exclusive global development and commercialisation rights outside China to build a focused cardiovascular franchise.
The chart below illustrates recent trends in China’s outbound drug licensing, highlighting both deal counts and upfront payments.
In 2025, China’s innovative drug outbound licensing activity reached record highs: $135.6bn in total deal value, $7.0bn in upfront payments, and 157 transactions. The use of NewCo models increased from six deals in 2024 to nine in 2025.
Turning China’s innovation advantage into deal success
As innovation continues to globalise, China is emerging as a central hub for life sciences dealmaking, combining speed, scale, and scientific capability that are increasingly difficult to replicate elsewhere. For dealmakers, partnering successfully with Chinese biotechs will require a deliberate approach that navigates cross-border regulatory complexity, reinforces data and intellectual property protections, and uses innovative structures to balance risk while preserving strategic flexibility.
Global health industries M&A values rose by 46% in 2025, despite a drop in volumes of 5%. This performance was underpinned by 11 megadeals (transactions valued greater than $5bn), up from three in 2024.
While each region accounted for roughly one-third of global deal volumes, Asia Pacific grew the most, up 12% in 2025, compared to a 5% increase in Europe, the Middle East, and Africa (EMEA) and a drop of 23% in the Americas. Much of the growth in Asia Pacific’s M&A activity was due to a 53% increase in China dealmaking, with investors attracted to the country’s innovative drug development landscape. The Americas continued to dominate in terms of deal value, representing nearly two-thirds of total deal value and nine megadeals.
In 2026, M&A will be the catalyst for business model reinvention, helping leaders unlock digital capabilities, accelerate innovation, and reposition for consumer-centred care. Deals will drive business model reinvention across all sectors, from biopharma and medtech to health services and digital health.
Cross-border partnerships will become more important. As business models evolve, divestitures will sit alongside acquisitions. And as AI matures, data-driven diligence, integration, and value creation will increasingly separate leaders from laggards.
The imperative is clear: act early, transact with purpose, and build momentum towards an AI-enabled prevention-led health system.