Rising global populations with advanced needs make one fact certain—we are at a crossroads when it comes to energy production. On one hand, the world is going to need more electricity than ever before. On the other hand, environmental considerations play a major part in our choices. This edition takes a pragmatic look at the long-term plans and actions that will be required to move the energy transformation ahead. That’s where nuclear power continues to fit in, according to many scientists and policy makers. Nuclear faces challenges, of course, but how they are being met is the subject of this issue of Gridlines.